Avasimibe

  • Chemical Properties
CAS No. 166518-60-1 Cat. No. BCP02302
Name Avasimibe
Synonyms CI-1011;CI1011;CI 1011;PD-148515;PD148515;PD 148515;
Formula C29H43NO4S M. Wt 501.72
  • Biological Activity
Description Avasimibe is an ACAT inhibitor (IC50 = 3.3 μM). Inhibits cholesterol esterification and reduces plasma cholesterol levels in rats. Also inhibits tumor growth and prolongs survival time in a melanoma mouse model and reduces tumor growth and metastasis in a pancreatic cancer mouse model.
Pathways Protease/Metabolic Enzyme 
Targets DGAT 

Structure

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