AT7519 HCl
| CAS号 | 902135-91-5 | 货号 | BCP01950 |
| 中文名 | AT7519 HCl | ||
| 英文名 | AT7519 HCl | ||
| 中文别名 | |||
| 英文别名 | AT 7519 HCl;AT-7519 HCl;AT7519 Hydrochloride ;AT-7519 Hydrochloride;AT 7519 Hydrochloride; | ||
| 分子式 | C16H17Cl2N5O2.HCl | 分子量 | 418.71 |
| 生物活性 | AT7519 HCl is a potent inhibitor of CDKs, with IC50s of 210, 47, 100, 13, 170, and <10 nM for CDK1, CDK2, CDK4 to CDK6, and CDK9, respectively.AT-7519 is an orally bioavailable small molecule CDK inhibitor with potential antineoplastic activity. AT7519M selectively binds to and inhibits cyclin dependent kinases (CDKs), which may result in cell cycle arrest, induction of apoptosis, and inhibition of tumor cell proliferation. CDKs are serine/theronine kinases involved in regulation of the cell cycle and may be overexpressed in some types of cancer cells. | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | CDK | ||
结构式
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