PIT 1
| CAS No. | 53501-41-0 | Cat. No. | BCP27689 |
| Name | PIT 1 | ||
| Synonyms | PIT-1;PIT1; | ||
| Formula | C14H10ClN3O4S | M. Wt | 351.76 |
| Description | PIT-1 is a selective nonphosphoinositide inhibitor that specifically disrupts PIP3/Akt PH domain binding with an IC50 value of 31 μM. PIT-1 suppresses PI3K-PDK1-Akt-dependent phosphorylation, which has been shown to reduce cell viability and induce apoptosis in PTEN-deficient U87MG glioblastoma cells (IC50 = 37 μM). | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | AKT | ||
Structure
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