BIBR-1532
| CAS号 | 321674-73-1 | 货号 | BCP01934 |
| 中文名 | BIBR-1532 | ||
| 英文名 | BIBR-1532 | ||
| 中文别名 | |||
| 英文别名 | BIBR1532;BIBR 1532; | ||
| 分子式 | C21H17NO3 | 分子量 | 331.36 |
| 生物活性 | BIBR 1532 exhibits an non-competitive inhibitory effect on telomerase activity. [1] In JVM13 leukemia cell line, BIBR 1532 shows an antiproliferative effect in a dose-dependent range with IC50 of 52 μM, and similar results are also observed in other leukemia cell lines including Nalm-1, HL-60, and Jurkat. In addition, BIBR 1532 results in a direct antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56 μM without affecting the proliferative capacity of normal hematopoietic progenitor cells. BIBR 1532 (2.5 μM) reduces colony-forming ability, and induces telomere length shortening as well as chemotherapeutic sensitization by inhibiting telomerase activity in MCF-7/WT and melphalan-resistant MCF-7/MlnR cell lines. In T-cell prolymphocytic leukemia (T-PLL), BIBR 1532 shows selective cytotoxic effects in a dose-dependent manner and BIBR 1532-treated cells also demonstrates nuclear condensation and formation of apoptotic bodies morphologically compatible with apoptosis. A re | ||
| 信号通路 | Cell Cycle/DNA Damage | ||
| 靶 点 | Telomerase | ||
结构式
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