BIBR-1532

参考资料仅供科学研究，不可用于个人用途。

货号：BCP01934CAS号：321674-73-1纯度：98%

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CAS号	321674-73-1	货号	BCP01934
中文名	BIBR-1532
英文名	BIBR-1532
中文别名
英文别名	BIBR1532;BIBR 1532;
SMILES
化学名称
分子式	C21H17NO3	分子量	331.36
纯度	98%	配送	惯例下常温包邮
产品描述	BIBR 1532 exhibits an non-competitive inhibitory effect on telomerase activity. [1] In JVM13 leukemia cell line, BIBR 1532 shows an antiproliferative effect in a dose-dependent range with IC50 of 52 μM, and similar results are also observed in other leukemia cell lines including Nalm-1, HL-60, and Jurkat. In addition, BIBR 1532 results in a direct antiproliferative effect on acute myeloid leukemia (AML) with IC50 of 56 μM without affecting the proliferative capacity of normal hematopoietic progenitor cells. BIBR 1532 (2.5 μM) reduces colony-forming ability, and induces telomere length shortening as well as chemotherapeutic sensitization by inhibiting telomerase activity in MCF-7/WT and melphalan-resistant MCF-7/MlnR cell lines. In T-cell prolymphocytic leukemia (T-PLL), BIBR 1532 shows selective cytotoxic effects in a dose-dependent manner and BIBR 1532-treated cells also demonstrates nuclear condensation and formation of apoptotic bodies morphologically compatible with apoptosis. A re