特利加压素
| CAS号 | 14636-12-5 | 货号 | BCP02061 |
| 中文名 | 特利加压素 | ||
| 英文名 | Terlipressin | ||
| 中文别名 | |||
| 英文别名 | Glypressin;Gly Gly Gly 8 Lys vasopressin; | ||
| 分子式 | C52H74N16O15S2 | 分子量 | 1227.37 |
| 生物活性 | Terlipressin is a synthetic triglycyllysine derivative of vasopressin with vasoconstrictive, antihemorrhagic, and antidiuretic properties. Upon intravenous administration, terlipressin, an inactive prodrug, is biotransformed to its active moiety, lysine vasopressin (LVP), a nonselective vasopressin analogue with affinity for vasopressin receptors V1 (V1a), V2 and V3 (V1b). As a V1 agonist, terlipressin increases systemic vascular resistance, particularly in the splanchnic area, resulting in a decrease of portal pressure. V1 binding also promotes platelet aggregation and glycogenolysis, while V3 binding induces adrenocorticotropic hormone (ACTH) secretion. Compared to vasopressin, terlipressin has a minimal effect on V2 receptors, which are responsible for promotion of water reabsorption in the collecting ducts of the kidney via stimulation of cyclic AMP production. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Vasopressin Receptor | ||
结构式
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