Tiplaxtinin
| CAS号 | 393105-53-8 | 货号 | BCP02216 |
| 中文名 | Tiplaxtinin | ||
| 英文名 | Tiplaxtinin | ||
| 中文别名 | |||
| 英文别名 | PAI-039;PAI 039;PAI039; | ||
| 分子式 | C24H16F3NO4 | 分子量 | 439.38 |
| 生物活性 | Tiplaxtinin, also known as PAI-039, is a novel plasminogen activator inhibitor-1 (PAI-1) inhibitor. The pharmacokinetic profile of PAI-039 indicated an oral bioavailability of 43 +/- 15.3% and a plasma half-life of 6.2 +/- 1.3 h. PAI-039 is an orally active prothrombolytic drug that inhibits PAI-1 and accelerates fibrinolysis while maintaining normal coagulation in a model of coronary occlusion . PAI-039 exerts antithrombotic efficacy in rat models of arterial and venous vascular injury without effecting platelet aggregation. PAI-039 as a novel therapeutic may improve diabetic wound closure. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | PAI1 | ||
结构式
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