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| CAS号 | 393105-53-8 | 货号 | BCP02216 |
| 中文名 | Tiplaxtinin | ||
| 英文名 | Tiplaxtinin | ||
| 中文别名 | |||
| 英文别名 | PAI-039;PAI 039;PAI039; | ||
| SMILES | O=C(O)C(C1=CN(CC2=CC=CC=C2)C3=C1C=C(C4=CC=C(OC(F)(F)F)C=C4)C=C3)=O | ||
| 化学名称 | |||
| 分子式 | C24H16F3NO4 | 分子量 | 439.38 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | Tiplaxtinin, also known as PAI-039, is a novel plasminogen activator inhibitor-1 (PAI-1) inhibitor. The pharmacokinetic profile of PAI-039 indicated an oral bioavailability of 43 +/- 15.3% and a plasma half-life of 6.2 +/- 1.3 h. PAI-039 is an orally active prothrombolytic drug that inhibits PAI-1 and accelerates fibrinolysis while maintaining normal coagulation in a model of coronary occlusion . PAI-039 exerts antithrombotic efficacy in rat models of arterial and venous vascular injury without effecting platelet aggregation. PAI-039 as a novel therapeutic may improve diabetic wound closure. | ||
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