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CAS号 | 2254001-81-3 | 货号 | BCP30356 |
中文名 | ZK824859 | ||
英文名 | ZK824859 | ||
中文别名 | |||
英文别名 | ZK-824859; ZK 824859;2271122-53-1; | ||
SMILES | CC[C@@H](OC1=NC(OC2=CC(C3=CC=CC(CN)=C3)=CC(C)=C2)=C(F)C=C1F)C(O)=O | ||
化学名称 | |||
分子式 | C23H22F2N2O4 | 分子量 | 428.44 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | ZK824859 (ZK-824859) is a potent, selective urokinase plasminogen activator (uPA) inhibitor with IC50 of 79 nM (human uPA), displays little to no inhibitory activity against tPA and Plasmin (IC50>1 uM); ZK 824859 is 5 fold less potent and has lost selectivity in mouse: uPA IC50=410 nM; tPA IC50=910 nM; plasmin IC50=1600 nM; demonstrates efficacy in either acute or chronic mouse EAE models. |
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