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CAS号 | 1103928-13-7 | 货号 | BCP30130 |
中文名 | TM 5275 | ||
英文名 | TM 5275 | ||
中文别名 | |||
英文别名 | TM-5275;TM5275; | ||
SMILES | O=C(O)C1=CC(Cl)=CC=C1NC(COCC(N2CCN(C(C3=CC=CC=C3)C4=CC=CC=C4)CC2)=O)=O | ||
化学名称 | |||
分子式 | C28H28ClN3O5 | 分子量 | 521.99 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | TM 5275 is selective, orally active inhibitor of plasminogen activator inhibitor-1 (PAI-1; IC50 value 6.95 µM in tissue plasminogen activator-dependent peptide hydrolysis essay) with antithrombotic benefits devoid of bleeding effect in rodents and nonhuman primates, and with impressive bioavailability.TM 5275 prolongs tPA retention and enhances plasmin generation on the vascular endothelial cell (VEC) surface as a result of PAI-1 inhibition. |
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