普瑞利韦
| CAS号 | 348086-71-5 | 货号 | BCP08742 |
| 中文名 | 普瑞利韦 | ||
| 英文名 | Pritelivir | ||
| 中文别名 | |||
| 英文别名 | BAY57-1293; BAY 57-1293; BAY-57-1293; BAY571293; BAY 571293; BAY-571293; AIC-316; AIC 316; AIC316; | ||
| 分子式 | C18H18N4O3S2 | 分子量 | 402.49 |
| 生物活性 | Pritelivir is a potent helicase primase inhibitor. BAY 57-1293 inhibits replication of herpes simplex virus (HSV) type 1 and type 2 in the nanomolar range in vitro by abrogating the enzymatic activity of the viral primase-helicase complex. In various rodent models of HSV infection the antiviral activity of BAY 57-1293 in vivo was found to be superior compared to all compounds currently used to treat HSV infections. The compound shows profound antiviral activity in murine and rat lethal challenge models of disseminated herpes, in a murine zosteriform spread model of cutaneous disease, and in a murine ocular herpes model. It is active in parenteral, oral, and topical formulations. | ||
| 信号通路 | Microbiology/Virology | ||
| 靶 点 | HSV | ||
结构式
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