CVT-10216
  • 化学数据
CAS号 1005334-57-5 货号 BCP27995
中文名 CVT-10216
英文名 CVT-10216
中文别名
英文别名 CVT10216; CVT 10216;
分子式 C24H19NO7S 分子量 465.48
  • 用途
生物活性 CVT-10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT-10216 increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents, including deprivation-induced drinking. Moreover, CVT-10216 also prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking even when alcohol is not available (i.e., no acetaldehyde). Alcohol stimulates DA release in the NAc, which is thought to contribute to increased drinking and relapse in alcoholism. CVT-10216 prevents alcohol-induced increases in NAc DA without changing basal levels.
信号通路 Protease/Metabolic Enzyme 
靶 点 ALDH 

结构式

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