CVT-10216

参考资料仅供科学研究，不可用于个人用途。

货号：BCP27995CAS号：1005334-57-5纯度：98%

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CAS号	1005334-57-5	货号	BCP27995
中文名	CVT-10216
英文名	CVT-10216
中文别名
英文别名	CVT10216; CVT 10216;
SMILES	O=C(O)C1=CC=CC(COC2=CC=C3C(C(C4=CC=C(NS(=O)(C)=O)C=C4)=COC3=C2)=O)=C1
化学名称
分子式	C24H19NO7S	分子量	465.48
纯度	98%	配送	惯例下常温包邮
产品描述	CVT-10216 is a potent and selective, reversible inhibitor of aldehyde dehydrogenase 2 (ALDH2) (IC50 values are 29 and 1300 nM for ALDH2 and ALDH1, respectively). CVT-10216 increases acetaldehyde after alcohol gavage and inhibits 2-bottle choice alcohol intake in heavy drinking rodents, including deprivation-induced drinking. Moreover, CVT-10216 also prevents operant self-administration and eliminates cue-induced reinstatement of alcohol seeking even when alcohol is not available (i.e., no acetaldehyde). Alcohol stimulates DA release in the NAc, which is thought to contribute to increased drinking and relapse in alcoholism. CVT-10216 prevents alcohol-induced increases in NAc DA without changing basal levels.