MG101

  • Chemical Properties
CAS No. 110044-82-1 Cat. No. BCP28014
Name MG101
Synonyms Calpain Inhibitor I; MG-101; MG 101; ALLN; AcLLnLCHO; Ac-LLnL-CHO;Ac-Leu-Leu-Nle-Aldehyde;Acetylleucyl-leucyl-norleucinal;
Formula C20H37N3O4 M. Wt 383.53
  • Biological Activity
Description MG-101 is a calpain inhibitor (IC50 = 0.09 μM) that activates p53-dependent apoptosis in tumor cell lines. Activities of MG-101 includes: (1) reduce colon injury caused by dinitrobenzene sulphonic acid; (2) overcome acquired resistance to TRAIL; (3) protect against atractyloside-induced toxicity. (4). reduce colon injury caused by dinitrobenzene sulphonic acid.
Pathways Protease/Metabolic Enzyme 
Targets Proteasome 

Structure

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