LB42708
| CAS号 | 226929-39-1 | 货号 | BCP09683 |
| 中文名 | LB42708 | ||
| 英文名 | LB42708 | ||
| 中文别名 | |||
| 英文别名 | LB-42708; LB 42708; | ||
| 分子式 | C30H27BrN4O2 | 分子量 | 555.46 |
| 生物活性 | LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | FTase | ||
结构式
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