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CAS号 | 226929-39-1 | 货号 | BCP09683 |
中文名 | LB42708 | ||
英文名 | LB42708 | ||
中文别名 | |||
英文别名 | LB-42708; LB 42708; | ||
SMILES | C1COCCN1C(=O)C2=CN(C=C2C3=CC=CC4=CC=CC=C43)CC5=CN=CN5CC6=CC=C(C=C6)Br | ||
化学名称 | |||
分子式 | C30H27BrN4O2 | 分子量 | 555.46 |
纯度 | 98% | 配送 | 惯例下常温包邮 |
产品描述 | LB42708 is a potent, orally active and selective nonpeptidic farnesyltransferase inhibitor (FTase inhibitor). LB42708 inhibited VEGF-induced Ras activation and subsequently suppressed angiogenesis in vitro and in vivo by blocking the mitogen-activated protein kinase kinase/extracellular signal-regulated kinase/p38 mitogen-activated protein kinase (MAPK) and phosphatidylinositol 3-kinase (PI3K)/Akt/endothelial nitric-oxide synthase pathways in endothelial cells without altering FAK/Src activation. |
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