ABT-100 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP42635CAS号：450839-40-4纯度：98%

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CAS号	450839-40-4	货号	BCP42635
中文名	ABT-100
英文名	ABT-100
中文别名
英文别名	ABT 100; ABT100; A367074; A 367074; A-367074;
SMILES	CN1C=NC=C1C(COC2=C(C=C(C=C2)C#N)C3=CC=C(C=C3)OC(F)(F)F)(C4=CC=C(C=C4)C#N)O
化学名称
分子式	C27H19F3N4O3	分子量	504.46
纯度	98%	配送	惯例下常温包邮
产品描述	ABT-100 is an orally bioavailable farnesyltransferase inhibitor. ABT-100 inhibited proliferation of cells in vitro carrying oncogenic H-Ras (EJ-1 bladder; IC(50) 2.2 nmol/L), Ki-Ras (DLD-1 colon, MDA-MB-231 breast, HCT-116 colon, and MiaPaCa-2 pancreatic; IC(50) range, 3.8-9.2 nmol/L), and wild-type Ras (PC-3 and DU-145; IC(50), 70 and 818 nmol/L, respectively) as well as clonogenic potential. ABT-100 shows 70% to 80% oral bioavailability in mice. ABT-100 regressed EJ-1 tumors (2-12.5 mg/kg/d s.c., every day for 21 days) and showed significant efficacy in DLD-1, LX-1, MiaPaCa-2, or PC-3 tumor-bearing mice (6.25-50 mg/kg/d s.c. once daily or twice daily orally).