洛那法尼

参考资料仅供科学研究，不可用于个人用途。

货号：BCP07027CAS号：193275-84-2纯度：98%

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CAS号	193275-84-2	货号	BCP07027
中文名	洛那法尼
英文名	Lonafarnib
中文别名
英文别名	Sarasar;Sch 66336;Sch-66336;Sch66336;
SMILES
化学名称
分子式	C27H31Br2ClN4O2	分子量	638.82
纯度	98%	配送	惯例下常温包邮
产品描述	SCH66336 at concentration ranging from 0.1 μM to 8 μM suppress growth and induce apoptosis of human head and neck squamous carcinoma cells (HNSCC) in a dose and time dependent manner. SCH66336 (8 μM) suppresses protein kinase B/Akt activity as well as the phosphorylation of the Akt substrates glycogen synthase kinase (GSK)-3β, forkhead transcription factor, and BAD in SqCC/Y1 cells. SCH66336 demonstrate variable antiproliferative effects against the cell lines, with IC50 ranging from 0.6 μM to 32.3 μM. Lonafarnib induces a CCAAT/enhancer-binding protein homologous protein (CHOP)-dependent transactivation of the DR5 promoter, thus induces CHOP-dependent DR5 up-regulation. Lonafarnib (< 10 μM) activates caspase-8 and its downstream caspases, thus induces caspase-8-dependent apoptosis in H1792 cells. Lonafarnib (5 μM) up-regulate DR5 expression, increase cell-surface DR5 distribution, and enhance tumor necrosis factor-related apoptosis-inducing ligand-induced apoptosis in H1792 cells.