Roniciclib
  • 化学数据
CAS号 1223498-69-8 货号 BCP28164
中文名 Roniciclib
英文名 Roniciclib
中文别名
英文别名 BAY1000394; BAY1000394; BAY 1000394;
分子式 C18H21F3N4O3S 分子量 430.44
  • 用途
生物活性 Roniciclib, also known as BAY 1000394, is an orally bioavailable cyclin dependent kinase (CDK) inhibitor with potential antineoplastic activity. pan-CDK inhibitor BAY1000394 selectively binds to and inhibits the activity of CDK1/Cyclin B, CDK2/Cyclin E, CDK4/Cyclin D1, and CDK9/Cyclin T1, serine/threonine kinases that play key roles in the regulation of the cell cycle progression and cellular proliferation. Inhibition of these kinases leads to cell cycle arrest during the G1/S transition, thereby leading to an induction of apoptosis, and inhibition of tumor cell proliferation.
信号通路 Cell Cycle/DNA Damage 
靶 点 CDK 

结构式

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