Uprosertib
| CAS No. | 1047634-65-0 | Cat. No. | BCP28204 |
| Name | Uprosertib | ||
| Synonyms | GSK-2141795; GSK2141795; GSK 2141795; GSK795; GSK-795; GSK 795.; | ||
| Formula | C18H16Cl2F2N4O2 | M. Wt | 429.25 |
| Description | Uprosertib, also known as GSK2141795 and GSK795, is an orally bioavailable inhibitor of the serine/threonine protein kinase Akt (protein kinase B) with potential antineoplastic activity. Akt inhibitor GSK2141795 binds to and inhibits the activity of Akt, which may result in inhibition of the PI3K/Akt signaling pathway and tumor cell proliferation and the induction of tumor cell apoptosis. Activation of the PI3K/Akt signaling pathway is frequently associated with tumorigenesis and dysregulated PI3K/Akt signaling may contribute to tumor resistance to a variety of antineoplastic agents. | ||
| Pathways | PI3K/Akt/mTOR | ||
| Targets | AKT | ||
Structure
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