RX3117
  • 化学数据
CAS号 865838-26-2 货号 BCP10720
中文名 RX3117
英文名 RX3117
中文别名
英文别名 RX-3117;RX 3117; TV1360; TV1360; TV 1360; Fluorocyclopentenylcytosine;
分子式 C10H12FN3O4 分子量 257.22
  • 用途
生物活性 RX-3117, also known as TV-1360, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1).
信号通路 Cell Cycle/DNA Damage 
靶 点 Antimetabolite 

结构式

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