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| CAS号 | 865838-26-2 | 货号 | BCP10720 |
| 中文名 | RX3117 | ||
| 英文名 | RX3117 | ||
| 中文别名 | |||
| 英文别名 | RX-3117;RX 3117; TV1360; TV1360; TV 1360; Fluorocyclopentenylcytosine; | ||
| SMILES | |||
| 化学名称 | |||
| 分子式 | C10H12FN3O4 | 分子量 | 257.22 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | RX-3117, also known as TV-1360, is an orally available and potent DNA synthesis inhibitor with potential antineoplastic activity. Upon administration, the cytidine analogue RX-3117 is taken up by cells through a carrier-mediated transporter, phosphorylated by uridine cytidine kinase (UCK) and then further phosphorylated to its diphosphate (RX-DP) and triphosphate forms (RX-TP). The triphosphate form is incorporated into RNA and inhibits RNA synthesis. The diphosphate RX-DP is reduced by ribonucleotide reductase (RR) to dRX-DP; its triphosphate form (dRX-TP) is incorporated into DNA. In addition, RX-3117 also inhibits DNA methyltransferase 1 (DNMT1). | ||
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