TAS-102

参考资料仅供科学研究，不可用于个人用途。

货号：BCP28532CAS号：733030-01-8纯度：98%

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基本信息与产品描述

CAS号	733030-01-8	货号	BCP28532
关联产品	183204-74-2（替吡嘧啶） 183204-72-0（盐酸替吡嘧啶） 70-00-8（曲氟胸苷）
中文名	TAS-102
英文名	TAS-102
中文别名
英文别名	TAS102;TAS102;Trifluridine-tipiracil hydrochloride mixture;rifluridine-tipiracil hydrochloride mixture;
SMILES
化学名称
分子式	C29H34Cl2F6N8O12	分子量	871.5
纯度	98%	配送	惯例下常温包邮
产品描述	TAS-102 is an investigational drug candidate for metastatic colorectal cancer. It contains trifluridine (TFT) and Tipiracil hydrochloride (TTP) in a molar ratio of 1;0.5. Trifluridine is a nucleoside analog, and tipiracil hydrochloride is a thymidine phosphorylase inhibitor, which prevents rapid metabolism of trifluiridine, increasing the bioavailability of trifluiridine. After oral administration of TAS-102, TFT is phosphorylated to the active monophosphate form TF-TMP, which binds covalently to the active site of thymidylate synthase, thereby reducing the nucleotide pool levels required for DNA replication. Furthermore, the triphosphate form TF-TTP can be incorporated into DNA, which induces DNA fragmentation and leads to the inhibition of tumor growth. TPI exhibits a dual effect: 1) an anti-angiogenic effect mediated through the inhibition of thymidine phosphorylase, which plays an important role in nucleotide metabolism and a variety of development processes, including angiogenesis, 2) increased bioavailability of the normally short-lived antimetabolite TFT by preventing its degradation into the inactive form trifluorothymine (TF-Thy). The synergistic effect of the components in TAS-102 may demonstrate antitumor activity in 5-FU-resistant cancer cells.

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TAS-102

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