MI 2 MALT1 inhibitor
| CAS号 | 1047953-91-2 | 货号 | BCP11666 |
| 中文名 | MI 2 MALT1 inhibitor | ||
| 英文名 | MI 2 MALT1 inhibitor | ||
| 中文别名 | |||
| 英文别名 | MI-2;MI2; | ||
| 分子式 | C19H17Cl3N4O3 | 分子量 | 455.72 |
| 生物活性 | MI-2 selectively killed ABC-DLBCL cell lines with CD79A/B, CARMA1, and/or MYD88 mutations but not those occurring in proteins downstream of MALT1, including those with A20 homozygous deletion or TAK1 mutation. Both MI-2 and Z-VRPR-FMK reduced nuclear c-REL to a similar extent, without affecting whole-cell levels of this protein. In both cell lines, exposure to MI-2 caused a clear reduction of nuclear c-REL whereas it did not affect p65 levels. | ||
| 信号通路 | NFκB | ||
| 靶 点 | MALT1 | ||
结构式
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