甲基泼尼松龙琥珀酸钠
| CAS号 | 2375-03-3 | 货号 | BCP11883 |
| 中文名 | 甲基泼尼松龙琥珀酸钠 | ||
| 英文名 | Methylprednisolone sodium succinate | ||
| 中文别名 | |||
| 英文别名 | 6 alpha-Methylprednisolone Sodium Hemisuccinate;6α-Methylprednisolone 21-hemisuccinate sodium salt; | ||
| 分子式 | C26H33NaO8 | 分子量 | 496.53 |
| 生物活性 | Methylprednisolone Sodium Succinate is the sodium succinate salt of a synthetic glucocorticoid receptor agonist with immunosuppressive and anti-inflammatory effects. Methylprednisolone sodium succinate is converted into active prednisolone in the body, which activates glucocorticoid receptor mediated gene expression. This includes inducing synthesis of anti-inflammatory protein IkappaB-alpha and inhibiting synthesis of nuclear factor kappaB (NF-kappaB). As a result, proinflammatory cytokine production such as IL-1, IL-2 and IL-6 is down-regulated and cytotoxic T-lymphocyte activation is inhibited. Therefore, an overall reduction in chronic inflammation and autoimmune reactions may be achieved. | ||
| 信号通路 | GPCR/G Protein | ||
| 靶 点 | Glucocorticoid Receptor | ||
结构式
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