加兰他敏
| CAS号 | 510-77-0 | 货号 | BCP12248 |
| 中文名 | 加兰他敏 | ||
| 英文名 | Galanthaminone | ||
| 中文别名 | 那维啶;那维定; | ||
| 英文别名 | (-)-Narwedine;Narwedin; 3-Deoxy-3-oxo-galanthamine; | ||
| 分子式 | C17H19NO3 | 分子量 | 285.34 |
| 生物活性 | Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release. Absorption of galantamine is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers. | ||
| 信号通路 | Neuro Signaling Pathway | ||
| 靶 点 | AChE | ||
结构式
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