SR3335
| CAS No. | 293753-05-6 | Cat. No. | BCP13177 |
| Name | SR3335 | ||
| Synonyms | SR-3335;SR 3335; ML 176; ML-176; ML176; | ||
| Formula | C13H9F6NO3S2 | M. Wt | 405.34 |
| Description | SR3335, also known as ML 176, is a RORα selective inverse agonist. SR3335 directly binds to RORα, but not other RORs, and functions as a selective partial inverse agonist of RORα in cell-based assays. Furthermore, SR3335 suppresses the expression of endogenous RORα target genes in HepG2 involved in hepatic gluconeogenesis including glucose-6-phosphatase and phosphoenolpyruvate carboxykinase. SR3335 can be utilized as a chemical tool to probe the function of this receptor both in vitro and in vivo. SR3335 may hold utility for suppression of elevated hepatic glucose production in type 2 diabetics. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | ROR | ||
Structure
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