尼日利亚菌素
| CAS号 | 28380-24-7 | 货号 | BCP13661 |
| 中文名 | 尼日利亚菌素 | ||
| 英文名 | Nigericin | ||
| 中文别名 | 抗生素K178;阿扎霉素M;28643-80-3（尼日利亚菌素钠盐）; | ||
| 英文别名 | Azalomycin M; Polyetherin A; Helixin C; Antibiotic K178; Antibiotic X464; 28643-80-3（Nigericin sodium salt）; | ||
| 分子式 | C40H68O11 | 分子量 | 724.97 |
| 生物活性 | Nigericin is an antibiotic derived from Streptomyces hygroscopicus. Its isolation was described in the 1950s, and in 1968 the structure could be elucidated by X-ray crystallography. The structure and properties of nigericin are similar to the antibiotic monensin. Commercially it is obtained as a byproduct, or contaminant, at the fermentation of Geldanamycin. It is also called Polyetherin A, Azalomycin M, Helixin C, Antibiotic K178, Antibiotic X-464. Nigericin acts as an H+, K+, Pb2+ ionophore. Most commonly it is an antiporter of H+ and K+. In the past nigericin was used as an antibiotic active against gram positive bacteria. It inhibits the Golgi functions in Eukaryotic cells. Nigericin exhibits anticancer and anti-HIV activity. | ||
| 信号通路 | Ion Channel/Membrane Transporter Microbiology/Virology | ||
| 靶 点 | Potassium Channel Antibiotic | ||
结构式
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