AL082D06
  • 化学数据
CAS号 256925-03-8 货号 BCP28760
中文名 AL082D06
英文名 AL082D06
中文别名
英文别名 AL-082D06; AL 082D06;D06;D 06; D-06;
分子式 C23H24ClN3O2 分子量 409.91
  • 用途
生物活性 AL082D06, also known as D-06, is a nonsteroidal glucocorticoid receptor antagonist. AL082D06 binds specifically to GR with no measurable binding affinity to the progesterone receptor. AL082D06 binds with nanomolar affinity to the GR and has no detectable binding affinity for the highly related receptors for mineralocorticoids, androgens, estrogens, and progestins. AL082D06 inhibits glucocorticoid-mediated transcriptional regulation. AL082D06 binds competitively with steroids, likely occupying a similar site within the ligand-binding domain.
信号通路 GPCR/G Protein 
靶 点 Glucocorticoid Receptor 

结构式

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