STF-31
| CAS号 | 724741-75-7 | 货号 | BCP16022 |
| 中文名 | STF-31 | ||
| 英文名 | STF-31 | ||
| 中文别名 | |||
| 英文别名 | STF 31;STF31; | ||
| 分子式 | C23H25N3O3S | 分子量 | 423.53 |
| 生物活性 | in vitro: STF 31 is a glucose uptake inhibitor in RCC (renal cell carcinoma) 4 cells. By limiting glucose uptake in cancer cells, the immense energy requirements for the cancer cell is not met and the cell does not have the resources to rapidly proliferate.STF-31, which selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival. STF-31 decreases glycolysis by decreasing glucose transport and not by inhibiting a particular glycolytic step or enzyme. STE31 is a potent glucose transporter 1 (GLUT1). STF31 selectively kills RCCs by specifically targeting glucose uptake through GLUT1 and exploiting the unique dependence of these cells on GLUT1 for survival. Treatment with STF31 inhibits the growth of RCCs by binding GLUT1 directly and impeding glucose uptake in vivo without toxicity to normal tissue. STF-31 is toxic to hPSCs and efficient for selective elimination of hPSCs from mixed cultures. | ||
| 信号通路 | GPCR/G Protein Others Pathway | ||
| 靶 点 | Glucose Transporter Autophagy | ||
结构式
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