西立伐他汀
| CAS号 | 145599-86-6 | 货号 | BCP24254 |
| 中文名 | 西立伐他汀 | ||
| 英文名 | Cerivastatin | ||
| 中文别名 | |||
| 英文别名 | BAY-w-6228; BAY-w 6228; BAY-w6228;Rivastatin; | ||
| 分子式 | C26H33FNNaO5 | 分子量 | 481.53 |
| 生物活性 | Cerivastatin is a synthetic lipid-lowering agent. Cerivastatin competitively inhibits hepatic hydroxymethyl-glutaryl coenzyme A (HMG-CoA) reductase, the enzyme which catalyzes the conversion of HMG-CoA to mevalonate, a key step in cholesterol synthesis. This agent lowers plasma cholesterol and lipoprotein levels, and modulates immune responses by suppressing major histocompatibility complex II on interferon gamma-stimulated, antigen-presenting cells such as human vascular endothelial cells. Muscle toxicity (myopathy and rhabdomyolysis) precludes the clinical use of this agent. | ||
| 信号通路 | Protease/Metabolic Enzyme | ||
| 靶 点 | HMGCR | ||
结构式
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