ML264
| CAS号 | 1550008-55-3 | 货号 | BCP17456 |
| 中文名 | ML264 | ||
| 英文名 | ML264 | ||
| 中文别名 | |||
| 英文别名 | ML-264;ML 264;(E)-3-(3-chlorophenyl)-N-(2-((1,1-dioxidotetrahydro-2H-thiopyran-4-yl)(methyl)amino)-2-oxoethyl)acrylamide; | ||
| 分子式 | C17H21ClN2O4S | 分子量 | 384.88 |
| 生物活性 | ML-264 is a Krüppel-like factor 5 (KLF5) inhibitor That Potently Inhibits Growth of Colorectal Cancer. ML264 is highly active (IC50 = 29 nM is a cell-based assay for proliferation of DLD-1 cells, IC50 = 81 nM in a cell-based luciferase assay). It lacks cytotoxicity in the IEC-6 control cell line (IC50 >50 μM, <50% inhibition was observed at 100 μM). Robust activity was also seen in several other KLF5-expressing cell types as well (e.g., HCT116, IC50 = 560 nM; HT29, IC50 = 130 nM; SW620, IC50 = 430 nM). ML264 is a good candidate for in vivo anticancer studies, with great potential for use in long time-course in situ studies aimed to elucidate the role of KLF5 as a regulator of cellular proliferation and tumor formation in the intestinal epithelium. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | KLF | ||
结构式
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