(+/-)-Narwedine

Description	Narwedin is a competitive and reversible cholinesterase(AChE) inhibitor; is used for the treatment of mild to moderate Alzheimer's disease and various other memory impairments. IC50 value: Target: AChE Galanthaminone reduces the action of AChE and therefore tends to increase the concentration of acetylcholine in the brain. is also an allosteric ligand at nicotinic acetylcholine receptors. It has shown activity in modulating the nicotinic cholinergic receptors on cholinergic neurons to increase acetylcholine release. Absorption of galantamine is rapid and complete and shows linear pharmacokinetics. It is well absorbed with absolute oral bioavailability between 80 and 100%. It has a half-life of seven hours. Peak effect of inhibiting acetylcholinesterase was achieved about one hour after a single oral dose of 8 mg in some healthy volunteers.
Pathways	Neuro Signaling Pathway
Targets	AChE

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