HPI-4
  • 化学数据
CAS号 302803-72-1 货号 BCP18834
中文名 HPI-4
英文名 HPI-4
中文别名
英文别名 CiliobrevinA;HPI 4;HPI4;Hedgehog Pathway Inhibitor 4;
分子式 C17H9Cl2N3O2 分子量 358.18
  • 用途
生物活性 Ciliobrevin A, also known as HPI-4 and Hedgehog Pathway Inhibitor 4, is a Hedgehog pathway inhibitor. Treatment with HH pathway inhibitor-4 (HPI-4) could significantly decrease human chondrosarcoma cell proliferation, invasion and migration ability. Furthermore, HPI-4 could distinctly disturb HH pathway-mediated ciliogenesis and suppress primary cilia-related protein intraflagellar transport protein IFT88 expression. HH downstream effect molecular GLI2 was restrained to block parathyroid hormone-related protein and affect MAPK/ERK-regulated matrix metalloproteinases (MMP2 and MMP9). d HPI-4 could be a new therapeutic option specific to chondrosarcoma expressing elevated levels of HH pathway.
信号通路 Wnt/Stem Cell 
靶 点 Hedgehog 

结构式

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