CC-401 hydrochloride
| CAS号 | 1438391-30-0 | 货号 | BCP25004 |
| 中文名 | CC-401 hydrochloride | ||
| 英文名 | CC-401 hydrochloride | ||
| 中文别名 | |||
| 英文别名 | CC 401 HCl;CC-401 HCl;CC401 HCl;CC 401 hydrochloride;CC401 hydrochloride; | ||
| 分子式 | C22H25ClN6O | 分子量 | 424.93 |
| 生物活性 | CC-401 hydrochloride is a potent inhibitor of all three forms of JNK with Ki of 25 to 50 nM.CC-401 is a second generation ATP-competitive anthrapyrazolone c-Jun N terminal kinase (JNK) inhibitor with potential antineoplastic activity. Based on the chemistry of SP600125, another anthrapyrazolone inhibitor of JNK, CC-401 competitively binds the ATP binding site of JNK, resulting in inhibition of the phosphorylation of the N-terminal activation domain of transcription factor c-Jun; decreased transcription activity of c-Jun; and a variety of cellular effects including decreased cellular proliferation. | ||
| 信号通路 | MAPK Pathway | ||
| 靶 点 | JNK | ||
结构式
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