沙利度胺
| CAS号 | 50-35-1 | 货号 | BCP19772 |
| 中文名 | 沙利度胺 | ||
| 英文名 | Thalidomide | ||
| 中文别名 | |||
| 英文别名 | Thalomid; | ||
| 分子式 | C13H10N2O4 | 分子量 | 258.23 |
| 生物活性 | Thalidomide is a synthetic derivative of glutamic acid (alpha-phthalimido-glutarimide) with teratogenic, immunomodulatory, anti-inflammatory and anti-angiogenic properties. Thalidomide acts primarily by inhibiting both the production of tumor necrosis factor alpha (TNF-alpha) in stimulated peripheral monocytes and the activities of interleukins and interferons. This agent also inhibits polymorphonuclear chemotaxis and monocyte phagocytosis. In addition, thalidomide inhibits pro-angiogenic factors such as vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF), thereby inhibiting angiogenesis. | ||
| 信号通路 | Protease/Metabolic Enzyme Others Pathway | ||
| 靶 点 | E1 E2 E3 Enzyme PROTAC | ||
结构式
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