NSC781406
| CAS号 | 1676893-24-5 | 货号 | BCP20676 |
| 中文名 | NSC781406 | ||
| 英文名 | NSC781406 | ||
| 中文别名 | |||
| 英文别名 | |||
| 分子式 | C29H27F2N6O6S2 | 分子量 | 627.68 |
| 生物活性 | NSC781406 demonstrates potent PI3K inhibition (PI3Kα IC50=2.0 nM) that translates into BEL-7404 cells proliferation inhibition (IC50=20 nM). NSC781406 displays reasonable liver microsome stability. NSC781406 demonstrates cytotoxic activities against leukemia, non-small cell, lung cancer, colon cancer, central nervous system cancer, melanoma, ovarian cancer, renal cancer, prostate cancer, and breast cancer. It is potent against 60 cancer cell lines with a mean GI50 value of 65 nM, and with a GI50 value less than 10 nM against four cancer cell lines. | ||
| 信号通路 | PI3K/Akt/mTOR | ||
| 靶 点 | PI3K mTOR | ||
结构式
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