塞卡替尼富马酸盐
| CAS号 | 893428-72-3 | 货号 | BCP25711 |
| 中文名 | 塞卡替尼富马酸盐 | ||
| 英文名 | Saracatinib difumarate | ||
| 中文别名 | |||
| 英文别名 | AZD0530 difumarate;AZD-0530 difumarate;AZD 0530 difumarate; | ||
| 分子式 | C35H40ClN5O13 | 分子量 | 774.18 |
| 生物活性 | Saracatinib Difumarate is the difumarate salt of saracatinib, an orally available 5-, 7-substituted anilinoquinazoline with anti-invasive and anti-tumor activities. Saracatinib is a dual-specific inhibitor of Src and Abl, protein tyrosine kinases that are overexpressed in chronic myeloid leukemia cells. This agent binds to and inhibits these tyrosine kinases and affects cell motility, cell migration, adhesion, invasion, proliferation, differentiation, and survival. Specifically, Saracatinib inhibits Src kinase-mediated osteoclast bone resorption. | ||
| 上下游产品 | 379231-04-6（塞卡替尼） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | Src/Bcr Abl | ||
结构式
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