SR 12813
| CAS No. | 126411-39-0 | Cat. No. | BCP25726 |
| Name | SR 12813 | ||
| Synonyms | SR-12813;SR12813;GW 485801;GW-485801;GW485801; | ||
| Formula | C24H42O7P2 | M. Wt | 504.54 |
| Description | SR12813 is a potent and efficacious pregnane X receptor (PXR) activator with EC50 of 200 and 700 nM for human and rabbit PXR; only shows weak activition for rat and mouse PXR; inhibits cholesterol synthesis (IC50=1.2 uM) with no effect on fatty acid synthesis, reduces cellular HMG-CoA reductase activity with IC50 of 0.85 uM; induce CYP3A expression in primary hepatocytes. | ||
| Pathways | Protease/Metabolic Enzyme | ||
| Targets | HMGCR | ||
Structure
Part data of this page collected from the open network resources, so Biochempartner can not guarantee its accuracy.
For product details of different batches, please contact our Customer
- Service & Tech Support:orders@biochempartner.com
- Website:www.biochempartner.com
Products are for research use only and not for human use. We do not sell to patients.