Mavorixafor hydrochloride

CAS No.	880549-30-4	Cat. No.	BCP26048
Name	Mavorixafor hydrochloride
Synonyms	AMD 070 hydrochloride;AMD-070 hydrochloride;AMD070 HCl;
Formula	C21H27N5.HCl	M. Wt	385.93

Description	Mavorixafor is an orally bioavailable and potent CXCR4 inhibitor. AMD11070 is an antagonist of SDF-1α ligand binding (IC50 = 12.5 ± 1.3 nM), inhibits SDF-1 mediated calcium flux (IC50 = 9.0 ± 2.0 nM) and SDF-1α mediated activation of the CXCR4 receptor as measured by a Eu-GTP binding assay (IC50 =39.8 ± 2.5 nM) or a [(35)S]-GTPγS binding assay (IC50 =19.0 ± 4.1 nM), and inhibits SDF-1α stimulated chemotaxis (IC50 =19.0 ± 4.0 nM). AMD11070 abrogates melanoma cell migration and is significantly more effective than AMD3100. AMD11070 represents a novel therapeutic strategy for both B-RAF wild-type and mutated melanomas.
Related Products	558447-26-0（Mavorixafor） 2309699-17-8（Mavorixafor trihydrochloride）
Pathways	GPCR/G Protein
Targets	CXCR

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