Mirogabalin besylate

CAS No.	1138245-21-2	Cat. No.	BCP29292
Name	Mirogabalin besylate
Synonyms	DS-5565 besylate; DS 5565 besylate; DS5565 besylate; A-2000700;
Formula	C18H25NO5S	M. Wt	367.46

Description	Mirogabalin, also known as DS-5565, is an α2δ-1 ligand being developed for pain associated with diabetic peripheral neuropathy, fibromyalgia, and postherpetic neuralgia. Mirogabalin was estimated to be 17-fold more potent than pregabalin. Mirogabalin is being developed by Daiichi Sankyo and related to drugs such as gabapentin and pregabalin. Similarly to these drugs, mirogabalin binds to the α2δ calcium channels (1 and 2), but with significantly higher potency than pregabalin. It has shown promising results in Phase II clinical trials for the treatment of diabetic peripheral neuropathic pain.
Pathways	Ion Channel/Membrane Transporter
Targets	Calcium Channel

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