E-7090
| CAS号 | 1622204-21-0 | 货号 | BCP29727 |
| 中文名 | E-7090 | ||
| 英文名 | E-7090 | ||
| 中文别名 | |||
| 英文别名 | E 7090; E7090; | ||
| 分子式 | C32H37N5O6 | 分子量 | 587.67 |
| 生物活性 | E-7090 is a fibroblast growth factor receptor inhibitor potentially for the treatment of solid tumors. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3. In kinetic analyses of the interaction between E7090 and FGFR1 tyrosine kinase, E7090 associated more rapidly with FGFR1 than did the type II FGFR1 inhibitor ponatinib, and E7090 dissociated more slowly from FGFR1, with a relatively longer residence time, than did the type I FGFR1 inhibitor AZD4547, suggesting that its kinetics are more similar to the type V inhibitors, such as lenvatinib. | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FGFR | ||
结构式
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