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E-7090 结构式

E-7090

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货号 ：BCP29727CAS号 ：1622204-21-0纯度：98%
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  • 基本信息与产品描述
CAS号 1622204-21-0 货号 BCP29727
中文名 E-7090
英文名 E-7090
中文别名
英文别名 E 7090; E7090;
SMILES CNC(=O)N1C=CC2=CC(=C(C=C21)OCCOC)OC3=CC(=NC=C3)NC(=O)C4=CC=C(C=C4)C5CCN(CC5)CCO
化学名称
分子式 C32H37N5O6 分子量 587.67
纯度 98% 配送 惯例下常温包邮
产品描述 E-7090 is a fibroblast growth factor receptor inhibitor potentially for the treatment of solid tumors. E-7090 is a selective inhibitor of the tyrosine kinase activities of FGFR1, -2, and -3. In kinetic analyses of the interaction between E7090 and FGFR1 tyrosine kinase, E7090 associated more rapidly with FGFR1 than did the type II FGFR1 inhibitor ponatinib, and E7090 dissociated more slowly from FGFR1, with a relatively longer residence time, than did the type I FGFR1 inhibitor AZD4547, suggesting that its kinetics are more similar to the type V inhibitors, such as lenvatinib.
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