MAX-40279 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP46002CAS号：2070931-57-4纯度：98%

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CAS号	2070931-57-4	货号	BCP46002
关联产品	2388506-44-1（MAX-40279半己二酸） 2388506-43-0（MAX-40279半富马酸盐）
中文名	MAX-40279
英文名	MAX-40279
中文别名
英文别名	MAX 40279; MAX40279;
SMILES	CC1=C(C2=NC(=NC=C2S1)NC3=CN(N=C3)C4CCNCC4)C5=C(C=C(C=C5)F)OC
化学名称
分子式	C22H23FN6OS	分子量	438.52
纯度	98%	配送	惯例下常温包邮
产品描述	FLT3/FGFR Dual Kinase Inhibitor MAX-40279 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play key roles in cellular proliferation and survival.