MAX-40279
| CAS号 | 2070931-57-4 | 货号 | BCP46002 |
| 中文名 | MAX-40279 | ||
| 英文名 | MAX-40279 | ||
| 中文别名 | |||
| 英文别名 | MAX 40279; MAX40279; | ||
| 分子式 | C22H23FN6OS | 分子量 | 438.52 |
| 生物活性 | FLT3/FGFR Dual Kinase Inhibitor MAX-40279 is an orally bioavailable inhibitor of the fibroblast growth factor receptor (FGFR) and FMS-like tyrosine kinase 3 (FLT3; CD135; STK1; FLK2), with potential antineoplastic activity. Upon oral administration of FLT3/FGFR dual kinase inhibitor MAX-40279, this agent binds to and inhibits both FGFR and FLT3, including FLT3 mutant forms, which results in the inhibition of FGFR/FLT3-mediated signal transduction pathways. This inhibits proliferation in FGFR/FLT3-overexpressing tumor cells. FGFR, a family of receptor tyrosine kinases, is upregulated in many tumor cell types. FLT3, a class III receptor tyrosine kinase (RTK), is overexpressed or mutated in most B-lineage neoplasms and in acute myeloid leukemias. They both play key roles in cellular proliferation and survival. | ||
| 上下游产品 | 2388506-44-1（MAX-40279半己二酸 ） 2388506-43-0（MAX-40279半富马酸盐） | ||
| 信号通路 | Angiogenesis/Protein Tyrosine Kinase | ||
| 靶 点 | FLT3 FGFR | ||
结构式
本页面部分数据来自于公开的网络资源,所以瀚香生物不能保证其准确性。
不同批次的产品详情请咨询我们的客服：
- 全国免费电话：400-099-8200
- 在线客服:
瀚香生物（Biochempartner) 的所有产品和服务仅用于科学研究，禁止用于人体和治疗！