Donafenib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP34023CAS号：1130115-44-4纯度：98%

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CAS号	1130115-44-4	货号	BCP34023
中文名	Donafenib
英文名	Donafenib
中文别名
英文别名	Sorafenib (D3); CM-4307; CM 4307; CM4307;Bay 43-9006 (D3);
SMILES	CNC(=O)C1=NC=CC(=C1)OC2=CC=C(C=C2)NC(=O)NC3=CC(=C(C=C3)Cl)C(F)(F)F
化学名称
分子式	C21H13D3ClF3N4O3	分子量	467.85
纯度	98%	配送	惯例下常温包邮
产品描述	Donafenib is an orally available multikinase inhibitor that targets Raf kinase and various receptor tyrosine kinases (RTKs), with potential antineoplastic activity. Upon oral administration, donafenib binds to and blocks the activity of Raf kinase, and inhibits Raf-mediated signal transduction pathways. This inhibits cell proliferation in Raf-expressing tumor cells. In addition, this agent may inhibit unidentified RTKs, and thus may further block tumor cell proliferation in susceptible tumor cells. Raf, a serine/threonine protein kinase, plays a key role in the Raf/mitogen-activated protein kinase kinase (MEK)/extracellular signal-regulated kinase (ERK) signaling pathway. Deregulation of this pathway often results in tumor cell proliferation and survival.