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Vemurafenib 结构式

维罗非尼

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货号 :BCP43160CAS号 :1029872-54-5纯度:98%
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  • 基本信息与产品描述
CAS号 1029872-54-5 货号 BCP43160
关联产品 918504-65-1(维罗非尼)
中文名 维罗非尼
英文名 Vemurafenib
中文别名
英文别名 PLX4032;PLX-4032;PLX 4032;
SMILES CCCS(=O)(=O)NC1=C(C(=C(C=C1)F)C(=O)C2=CNC3=C2C=C(C=N3)C4=CC=C(C=C4)Cl)F
化学名称
分子式 C23H18ClF2N3O3S 分子量 489.92
纯度 98% 配送 惯例下常温包邮
产品描述 Vemurafenib is an orally bioavailable, ATP-competitive, small-molecule inhibitor of BRAF(V600E) kinase with potential antineoplastic activity. Vemurafenib selectively binds to the ATP-binding site of BRAF(V600E) kinase and inhibits its activity, which may result in an inhibition of an over-activated MAPK signaling pathway downstream in BRAF(V600E) kinase-expressing tumor cells and a reduction in tumor cell proliferation. Approximately 90% of BRAF gene mutations involve a valine-to-glutamic acid mutation at residue 600 (V600E); the oncogene protein product, BRAF(V600E) kinase, exhibits a markedly elevated activity that over-activates the MAPK signaling pathway. The BRAF(V600E) gene mutation has been found to occur in approximately 60% of melanomas, and in about 8% of all solid tumors, including melanoma, colorectal, thyroid and other cancers.
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