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| CAS号 | 1111636-35-1 | 货号 | BCP21016 |
| 中文名 | PF-04880594 | ||
| 英文名 | PF-04880594 | ||
| 中文别名 | |||
| 英文别名 | PF04880594; PF 04880594; | ||
| SMILES | N#CCCNC1=NC=CC(C2=CN(CC(F)F)N=C2C3=CN=C(NC=C4)C4=C3)=N1 | ||
| 化学名称 | |||
| 分子式 | C19H16F2N8 | 分子量 | 394.38 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | PF-04880594 is a RAF inhibitor, which induces ERK phosphorylation and RAF dimerization in those epithelial tissues that undergo hyperplasia. PF-04880594 stimulates production of the inflammatory cytokine interleukin 8 in HL-60 cells. Epithelial tissue hyperplasia induced by the RAF inhibitor PF-04880594 is attenuated by a clinically well-tolerated dose of the MEK inhibitor PD-0325901. The combination treatment with PF-04880594 and MEK inhibitors might greatly increase the safety and therapeutic index of RAF inhibitors for the treatment of melanoma and other cancers. | ||
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