参考资料
在线咨询
购买咨询即时询价 ×
* 必填项
请填妥以下表格,您将在一分钟内得到邮件机器人给你的报价。
Inquiry Online
×
* Required Fields.
Please complete the form below and we will contact you shortly.
Bulk Inquiry
×
* Required Fields.
Please complete the form below and we will contact you shortly.
| CAS号 | 630124-46-8 | 货号 | BCP21589 |
| 中文名 | AST-487 | ||
| 英文名 | AST-487 | ||
| 中文别名 | |||
| 英文别名 | NVPAST487; AST 487; AST487;NVP-AST-487; | ||
| SMILES | CCN1CCN(CC1)CC2=C(C=C(C=C2)NC(=O)NC3=CC=C(C=C3)OC4=NC=NC(=C4)NC)C(F)(F)F | ||
| 化学名称 | |||
| 分子式 | C26H30F3N7O2 | 分子量 | 529.56 |
| 纯度 | 98% | 配送 | 惯例下常温包邮 |
| 产品描述 | AST487, also known as NVP- AST487, is a RET kinase inhibitor/FLT3 inhibitor. The RET kinase has emerged as a promising target for the therapy of medullary thyroid cancers (MTC) and of a subset of papillary thyroid cancers. NVP- AST487 has an IC(50) of 0.88 mumol/L on RET kinase, inhibits RET autophosphorylation and activation of downstream effectors, and potently inhibited the growth of human thyroid cancer cell lines with activating mutations of RET but not of lines without RET mutations. NVP- AST487 induced a dose-dependent growth inhibition of xenografts of NIH3T3 cells expressing oncogenic RET, and of the MTC cell line TT in nude mice. NVP- AST487 inhibited calcitonin gene expression in vitro in TT cells, in part, through decreased gene transcription. | ||
在购买和使用瀚香生物产品的过程中，您遇到的任何问题，都可以咨询我们的免费热线：400-099-8200，或者和我们的客服 
。 我们竭诚解决您的一切疑惑，保证您的舒心顺畅。
。 我们竭诚解决您的一切疑惑，保证您的舒心顺畅。相关产品推荐
查看更多 >
Tags:AST-487 供应商,AST-487 购买,AST-487 生产,AST-487 批量,AST-487 供应,AST-487 订购,AST-487 采购