Emavusertib 新

参考资料仅供科学研究，不可用于个人用途。

货号：BCP33271CAS号：1801344-14-8纯度：98%

规格	价格(CNY)	是否现货	购买咨询
50.00 mg	￥1000.00	In-stock	购买咨询
100.00 mg	￥1500.00	In-stock	购买咨询
250.00 mg	￥2500.00	In-stock	购买咨询

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CAS号	1801344-14-8	货号	BCP33271
中文名	Emavusertib
英文名	Emavusertib
中文别名
英文别名	CA 4948; CA4948;CA-4948;
SMILES	CC1=NC=CC(=C1)C2=NC(=CO2)C(=O)NC3=CC4=C(N=C3N5CCC(C5)O)N=C(O4)N6CCOCC6
化学名称
分子式	C24H25N7O5	分子量	491.51
纯度	98%	配送	惯例下常温包邮
产品描述	Emavusertib is an orally bioavailable, reversible inhibitor of interleukin-1 receptor-associated kinase 4 (IRAK4), with potential antineoplastic, immunomodulating and anti-inflammatory activities. Upon oral administration, emavusertib targets, binds to, and blocks the kinase activity of IRAK4. This inhibits IRAK4-mediated signaling, prevents the activation of IRAK4-mediated nuclear factor-kappa B (NF-kB) signaling and decreases the expression of inflammatory cytokines and certain pro-survival factors. This inhibits proliferation of IRAK4-overactivated tumor cells, which are found in cells harboring MYD88 activating mutations or those with overactivated toll-like receptor (TLR) pathways. In addition, CA-4948 may inhibit inflammation and immune-mediated cell destruction in inflammatory and auto-immune diseases where TLR or interleukin 1 receptor (IL-1R) signaling is overactivated and MYD88 is dysregulated. IRAK4, a serine/threonine-protein kinase that plays a key role in both the TLR and IL-1R signaling pathways, is activated though the adaptor protein MYD88 and links the TLR and IL-1R signaling pathway to the NF-kB pathway.